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It might cost up to $5m for 30 seconds but scoring an advertising slot in the Super Bowl is bound to be a huge victory for the game's sponsors.
Last year's game between the New England Patriots and Seattle Seahawks was the most watched in US television history, with more than 114.4 million viewers.
The adverts typically star high-profile names and are released online in advance in the hope of generating extra buzz.
Many advertisers have been skipping the crass humour and sex in recent years to play it relatively safe for the game's 50th anniversary this year.
Lisa Granatstein, an editor at Adweek, said: "Advertisers just don't want to blow it in 30 seconds on the Super Bowl so many are teeing up by producing teasers or rolling out the ad completely before the game, and this allows a big rollout on social media which does matter these days."
Budweiser's ad features Dame Helen Mirren telling people why drunken driving is a bad idea, while Bud Light creates its own political campaign using Amy Schumer and Seth Rogen.
"It's still early on, we may still see a viral hit but I predict this year will be a little bit more tempered in part because of the distraction of the political campaign and because everybody is playing, it seems, a little safe," added Ms Granatstein.
The Carolina Panthers will take on the Denver Broncos at the Levi's Stadium in Santa Clara, California, on Sunday 7 February.
Beyonce and Coldplay are due to perform in the famous half-time show.
Here are some of the adverts viewers can expect to see:
Harvey Keitel and Serena Williams call the new Mini Clubman car different names like "chick car" and "short man's car" before urging viewers to "defy labels".
Dame Helen Mirren calls herself a "notoriously frank and uncensored British lady" and lectures drunk drivers about why it's a terrible idea.
Amy Schumer and Seth Rogen give Bill and Hillary Clinton a run for their money in a spoof political advert as they form the Bud Light Party.
To the tune of Harry Nilsson's Without You, sausage dogs dressed up like hot dogs run excitedly toward people in ketchup costumes in a 'Wiener Stampede'.
Sheep in a meadow sing Queen's Somebody To Love, until their owner and a sheep dog drive up in a new Honda Ridgeline, which is also blasting the song.
Liam Neeson talks about the future in a sci-fi spot directed by Ridley Scott's son, Jake Scott, to promote an LG TV.
The first trailer for Matt Damon's return as Jason Bourne will premiere during Super Bowl 50 when fans will also find out what the title of the film is.
Mobile phone executives ask the rapper Drake to change the lyrics to his hit single Hotline Bling to sound more like a phone contract.
Actor Gary Sinese urges people to let go of financial stress, "let go and breathe" and have financial confidence.