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Seven people have been taken to hospital after a shooting at the Ohio State University campus, reported Sky News.
Students were told: "Run Hide Fight" in a tweet, as police rushed to the scene at around 10am local time.
Of the seven people being treated in hospital, two are in a stable condition but there are no details on the other five, the fire department said.
SWAT teams and other armed police descended on the campus in Columbus as officers on loud speaker warned students that the gunman is at large.
Police said just after 11.30am local time that the scene was secure and lockdown lifted.
CBS reported that one suspect had been killed.
Buckeye Alert: Active Shooter on campus. Run Hide Fight. Watts Hall. 19th and College.— OSU Emergency Mngmnt (@OSU_EMFP) November 28, 2016
The university's Emergency Management had urged people on campus to "wait for police officers directions" and to contact police only with information.
"Run, hide, fight" is standard protocol for active shooter situations, meaning: "Run", evacuate if possible; "Hide", get silently out of view; or "Fight", as a last resort, take action to disrupt or incapacitate the shooter if your life is in imminent danger.
Cassidie Baker, a student at the university, said she saw police or paramedics helping one person on the ground outside Watts Hall, an engineering building.
She said: "No one really knows what is happening, other than there's an active shooter."
With nearly 60,000 students at its main Columbus campus, Ohio State is one of America's largest universities.
Read more at skynews.com.